Beilstein J. Org. Chem.2013,9, 1533–1550, doi:10.3762/bjoc.9.175
Kristin D. Schleicher Timothy F. Jamison Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, United States 10.3762/bjoc.9.175 Abstract Synthetic studies on the antibiotic natural product ripostatinA have been carried out with the aim to
decarboxylation enables construction of the C15−C16 bond by an aldol reaction. The product of this transformation is of the correct oxidation state and potentially three steps removed from the targeted epoxide fragment.
Keywords: catalysis; natural product; nickel; reductive coupling; ripostatinA; synthesis
ribonucleic acid polymerase. These compounds inhibit chain initiation of RNA synthesis in Staphylococcus aureus, a particularly infectious bacterial strain with reported drug resistance to the antibiotics vancomycin and methicillin [3]. RipostatinA exists as an equilibrium mixture of ketone and hemiketal